Impact of the hypoxia inducible factor-1α (HIF-1α) pro582 ser polymorphism and its gene expression on Diabetic foot ulcers Sivakamasundari Pichu , Jayalalitha Sathiyamoorthy, Ezhilarasi Krishnamoorthy, Dhamodharan Umapathy, Vijay Viswanathan, Diabetes Research and Clinical Practice; 22 May 2015 Quote: Aim Adaptation to low oxygen tension (hypoxia) in cells and tissues leads to the transcriptional induction of series of genes and the primary factor mediating this response is the hypoxia-inducible factor-1α. This study was designed in order to examine the HIF-1α gene polymorphism, p582s (rs11549465) in Exon-12 of HIF-1α gene in diabetic subjects with and without foot ulcers (DFU) and to find its expression under these pathological conditions. Methods A total of 224 subjects from our tertiary care centre were included, which consists of healthy controls (n = 66), Type 2 Diabetic mellitus (T2DM) (n = 79) and T2DM with foot ulcers (DFU) (n = 79).
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Decreased HIF-1α gene expression on foot ulcer patients
